Drugs for weight loss: Part 4

Using other off label drugs

Other unorthodox weight loss experts claim that other not recommended drugs may also help in the weight loss program. These drugs are not approved for use in obesity. These drugs include thyroxin, diuretics and the anti diabetic agent, metformin.

The anti diabetic drug, metformin is an effective weight loss reducing agent and has been used by non diabetic individuals. However, in non diabetic individuals, the drug can cause profound drop in blood sugar and lead to coma. Thus daily blood glucose monitoring is mandatory.

The antidepressant bupropion (Wellbutrin) has also been associated with weight loss. When the drug is prescribed to patients with depression, weight loss has been a noticeable side effect.

Temporary weight loss can also occur with diuretics and thyroid hormone. However, these drugs have potent side effects but still are frequently abused by athletes and boxers.

Results

There is no doubt that no matter what weight loss drug is prescribed, most patients will initially lose 5-10% of their starting body weight. This is significantly more than any conventional behavior modifying treatments. The most important rule for success is that individuals have to have realistic goals. Setting sights at losing 10-15% of body weight in a year is reasonable but the majority of individuals are unrealistic and loose hope after a few months. For the physicians, it is essential to educate patient on a reasonable amount of weight loss. Physicians who promote 25-50% weight loss in a year are setting up all patients for failure.

Most weight loss experts now feel that it is essential to help patients lose 3-10% of body weight. Results indicate that medications plus aggressive life style changes can produce dramatic results. An important part of that strategy includes educating patients to stay on low-calorie, low-fat maintenance diets and continue to exercise. While losing 3-5% of the body weight may not sound too impressive and may not be the patient’s goal, these results combined with life style changes have shown a significant reduction in the risk of developing type 2 diabetes mellitus.